Publications

Edwin Thanarajah S, Ribeiro AH, Lee J, Winter NR, Stein F, Lippert RN, Hanssen R, Schiweck C, Fehse L, Bloemendaal M, Aichholzer M, Bouzouina A, Uckermark C, Welzel M, Repple J, Matura S, Meinert S, Bang C, Franke A, Leenings R, Konowski M, Ernsting J, Fisch L, Barkhau C, Thomas-Odenthal F, Usemann P, Teutenberg L, Straube B, Alexander N, Jamalabadi H, Nenadic I, Lügering A, Nitsch R, Kittel-Schneider S, Cryan JF, Reif A, Kircher T, Heider D, Dannlowski U, Hahn T. Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations. JAMA Psychiatry. 2025 Nov 1;82(11):1095-1102. doi: 10.1001/jamapsychiatry.2025.2579. PMID: 40991280; PMCID: PMC12461599.

 

Gestal-Mato U, Herhaus L. Autophagy-dependent regulation of MHC-I molecule presentation. J Cell Biochem. 2024 Nov;125(11):e30416. doi: 10.1002/jcb.30416. Epub 2023 May 1. PMID: 37126231.

 

Gruber J, Hanssen R, Qubad M, Bouzouina A, Schack V, Sochor H, Schiweck C, Aichholzer M, Matura S, Slattery DA, Zopf Y, Borgland SL, Reif A, Thanarajah SE. Impact of insulin and insulin resistance on brain dopamine signalling and reward processing - An underexplored mechanism in the pathophysiology of depression? Neurosci Biobehav Rev. 2023 Jun;149:105179. doi: 10.1016/j.neubiorev.2023.105179. Epub 2023 Apr 12. PMID: 37059404.

 

Hanssen R, Bouzouina A, Reif A, Edwin Thanarajah S. Connecting the dots: Insulin resistance and mental health. Neurosci Biobehav Rev. 2024 Mar;158:105549. doi: 10.1016/j.neubiorev.2024.105549. Epub 2024 Jan 17. PMID: 38242521.

 

Heering J, Hernandez-Olmos V, Ildefeld N, Liu T, Kaiser A, Naeem Z, Frömel T, Fleming I, Steinhilber D, Proschak E. Development and Characterization of a Fluorescent Ligand for Leukotriene B4 Receptor 2 in Cells and Tissues. J Med Chem. 2022 Feb 10;65(3):2023-2034. doi: 10.1021/acs.jmedchem.1c01589. Epub 2022 Jan 7. PMID: 34995452.

 

Herhaus L, Gestal-Mato U, Eapen VV, Mačinković I, Bailey HJ, Prieto-Garcia C, Misra M, Jacomin AC, Ammanath AV, Bagarić I, Michaelis J, Vollrath J, Bhaskara RM, Bündgen G, Covarrubias-Pinto A, Husnjak K, Zöller J, Gikandi A, Ribičić S, Bopp T, van der Heden van Noort GJ, Langer JD, Weigert A, Harper JW, Mancias JD, Dikic I. IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion. Cell. 2024 Dec 12;187(25):7285-7302.e29. doi: 10.1016/j.cell.2024.09.048. Epub 2024 Oct 30. PMID: 39481378.

 

Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov VV, Moroz YS, Nevermann S, Mathes M, Ehrler JHM, Alnouri MW, Wolf M, Haydo AS, Schmachtel T, Zaliani A, Höfner G, Kaiser A, Schubert-Zsilavecz M, Beck-Sickinger AG, Offermanns S, Gribbon P, Rieger MA, Merk D, Sisignano M, Steinhilber D, Proschak E. Development of a Potent and Selective G2A (GPR132) Agonist. J Med Chem. 2024 Jul 11;67(13):10567-10588. doi: 10.1021/acs.jmedchem.3c02164. Epub 2024 Jun 25. PMID: 38917049; PMCID: PMC11249017.

 

Hernandez-Olmos V, Heering J, Ildefeld N, Ehrler JHM, Kaps A, Rajkumar R, Marinescu B, Kaiser A, Macinkovic I, Elewa MAF, Alnouri MW, Elson L, Schubert-Zsilavecz M, Kallenborn-Gerhardt W, Schmidtko A, Müller S, Offermanns S, Steinhilber D, Weigert A, Proschak E. Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping. J Med Chem. 2025 Jan 23;68(2):1195-1221. doi: 10.1021/acs.jmedchem.4c01617. Epub 2025 Jan 13. PMID: 39803894.

 

Ildefeld N, Steinhilber D, Proschak E, Heering J. HTRF-based assay for detection of mono-ADP-ribosyl hydrolyzing macrodomains and inhibitor screening. iScience. 2024 Jun 20;27(7):110333. doi: 10.1016/j.isci.2024.110333. PMID:39055912; PMCID: PMC11269945.

 

Kiprina A, Teichmann T, Martín Giménez VM, Xu W, Sailer F, Windbergs M, Manucha W, Weigert A, Brandes RP. The endocannabinoid anandamide prevents TH17 programming of activated T lymphocytes while preserving TH1 responses. Front Pharmacol. 2024 Dec 20;15:1528759. doi: 10.3389/fphar.2024.1528759. PMID: 39759451; PMCID: PMC11695368.

 

Klaassen K, Kecman B, Stankovic S, Komazec J, Pavlovic S, Stojiljkovic M, Djordjevic M. Genomic profiling, implications for genotype-based treatment of 131 patients with phenylketonuria and characterization of novel p.Pro416Leu PAH variant. Sci Rep. 2025 Jun 5;15(1):19745. doi: 10.1038/s41598-025-04611-2. PMID: 40473815; PMCID: PMC12141581.

 

Lang A, Stiller T, Ildefeld N, Heitel P, Isigkeit L, Proschak E, Heering J, Schubert-Zsilavecz M, Merk D. Fatty Acid Mimetic Fragments as Liver Receptor Homologue-1 Modulators. ACS Pharmacol Transl Sci. 2025 Feb 12;8(3):673-678. doi:10.1021/acsptsci.4c00734. PMID: 40109748; PMCID: PMC11915031.

 

Lang A, Ildefeld N, Lillich FF, Kaiser A, Busch R, Marschner JA, Proschak E, Heering J, Schubert-Zsilavecz M, Merk D. Fragment-Based Discovery of Drug-like LRH-1 Agonists. ACS Med Chem Lett. 2025 Mar 20;16(4):575-582. doi:10.1021/acsmedchemlett.4c00604. PMID: 40236550; PMCID: PMC11995229.

 

Miletić N, Weckesser J, Mosler T, Rathore R, Hoffmann ME, Gehrtz P, Schlesiger S, Hartung IV, Berner N, Wilhelm S, Müller J, Adhikari B, Němec V, Sivashanmugam SA, Elson L, Holzmann H, Schwalm MP, Hoffmann L, Abdul Azeez KR, Müller S, Kuster B, Wolf E, Đikić I, Knapp S. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. doi:10.1021/acschembio.4c00812. Epub 2025 Feb 11. PMID: 39932098; PMCID:PMC11851430.

 

Nawa F, Sai M, Vietor J, Schwarzenbach R, Bitić A, Wolff S, Ildefeld N, Pabel J, Wein T, Marschner JA, Heering J, Merk D. Tuning RXR Modulators for PGC1α Recruitment. J Med Chem. 2024 Sep 26;67(18):16338-16354. doi:10.1021/acs.jmedchem.4c01231. Epub 2024 Sep 11. PMID: 39258574.

 

Roesmann F, Müller L, Klaassen K, Heß S, Widera M. Interferon-Regulated Expression of Cellular Splicing Factors Modulates Multiple Levels of HIV-1 Gene Expression and Replication. Viruses. 2024 Jun 11;16(6):938. doi: 10.3390/v16060938. PMID: 38932230; PMCID: PMC11209495.

 

Roesmann F, Sertznig H, Klaassen K, Wilhelm A, Heininger D, Heß S, Elsner C, Marschalek R, Santiago ML, Esser S, Sutter K, Dittmer U, Widera M. The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting. J Virol. 2024 Jul 23;98(7):e0053424. doi: 10.1128/jvi.00534-24. Epub 2024 Jun 20. PMID: 38899932; PMCID: PMC11265465.

 

Sailer FK, Palmer MA, Aliraj B, Heering J, Brockmann A, Elewa MAF, Röhrig A, Proschak E, Stepniak DT, Ramsey S, Brüne B, Weigert A. S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation. Front Pharmacol. 2025 Apr 24;16:1590816. doi: 10.3389/fphar.2025.1590816. PMID: 40342995; PMCID: PMC12058506.

 

Schiweck C, Aichholzer M, Brandt E, Schneider M, Meyer K, Hamzehloiya T, Qubad M, Uckermark C, Jacobsen L, Amaral K, Auer J, Bruno G, Zhao T, Bouzouina A, Schillo S, Hanssen R, Hahn T, Repple J, Matura S, Kingslake J, Reif A, Edwin Thanarajah S. The heart knows best: baseline heart rate variability as guide to transcutaneous auricular vagus nerve stimulation in depression. Transl Psychiatry. 2025 Dec 6;15(1):521. doi: 10.1038/s41398-025-03780-y. PMID: 41353184; PMCID: PMC12689627.

 

Schiweck C, Dalile B, Balliet A, Aichholzer M, Reinken H, Erhardt F, Freiling J, Bouzouina A, Uckermark C, Reif A, Verbeke K, van Oudenhove L, Edwin Thanarajah S. Circulating short chain fatty acids are associated with depression severity and predict remission from major depressive disorder. Brain Behav Immun Health. 2025 Jul 19;48:101070. doi: 10.1016/j.bbih.2025.101070. PMID: 40761299; PMCID: PMC12320157.

 

Seifert M, Kollenkirchen T, Ernst A, Rasoulinejad S, Koellner SMS, Schneider A, Luzarowski M, Lübbehusen N, Wu D, Kannt A, Safarian S. Glycan-based biological degraders targeting the cytokine immune axis. Communications Biol, 2026, Epub ahead of print, https://doi.org/10.1038/s42003-026-10001-9.

 

Staudt A, Ratai O, Bouzouina A, Fecher-Trost C, Shaaban A, Bzeih H, Horn A, Shaib AH, Klose M, Flockerzi V, Lauterbach MA, Rettig J, Becherer U. Localization of the Priming Factors CAPS1 and CAPS2 in Mouse Sensory Neurons Is Determined by Their N-Termini. Front Mol Neurosci. 2022 Apr 14;15:674243. doi: 10.3389/fnmol.2022.674243. PMID: 35493323; PMCID: PMC9049930.

 

Teichmann T, Pflüger-Müller B, Giménez VMM, Sailer F, Dirks H, Zehr S, Warwick T, Brettner F, Munoz-Tello P, Zimmer A, Tegeder I, Thomas D, Gurke R, Günther S, Heering J, Proschak E, Geisslinger G, Bibli IS, Heringdorf DMZ, Manucha W, Windbergs M, Knapp S, Weigert A, Leisegang MS, Kojetin D, Brandes RP. The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors. Br J Pharmacol. 2025 Mar;182(5):1164-1182. doi: 10.1111/bph.17366. Epub 2024 Nov 19. PMID: 39563075; PMCID: PMC11790392.

 

Zhao T, Schiweck C, Jamalambadi H, Meyer K, Brandt E, Schneider M, Aichholzer M, Qubad M, Bouzouina A, Schillo S, Hanssen R, Sonkusare S, Kingslake J, Beckenstrom A, Repple J, Reif-Leonhard C, Hahn T, Reif A, Edwin Thanarajah S. Transcutaneous vagus nerve stimulation improves emotional processing. J Affect Disord. 2025 Mar 1;372:96-105. doi: 10.1016/j.jad.2024.11.077. Epub 2024 Nov 28. PMID: 39615758.