Publications

2022

  1. Schebb NH, Kühn H, Kahnt AS, Rund KM, O'Donnell VB, Flamand N, Peters-Golden M, Jakobsson PJ, Weylandt KH, Rohwer N, Murphy RC, Geisslinger G, FitzGerald GA, Hanson J, Dahlgren C, Alnouri MW, Offermanns S, Steinhilber D. Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far? Front Pharmacol. 2022 Mar 2;13:838782. doi: 10.3389/fphar.2022.838782. PMID: 35308198; PMCID: PMC8924552.
  2. Flinspach AN, Zinn S, Zacharowski K, Balaban Ü, Herrmann E, Adam EH. Electroencephalogram-Based Evaluation of Impaired Sedation in Patients with Moderate to Severe COVID-19 ARDS. J Clin Med. 2022 Jun 17;11(12):3494. doi: 10.3390/jcm11123494. PMID: 35743572; PMCID: PMC9224742.
  3. Ruf S, Rajagopal S, Kadnur SV, Hallur MS, Rani S, Kristam R, Swaminathan S, Zope BR, Gondrala PK, Swamy I, Putta VPRK, Kandan S, Zech G, Schreuder H, Rudolph C, Elvert R, Czech J, Birudukota S, Siddiqui MA, Anand NN, Mane VS, Dittakavi S, Suresh J, Gosu R, Ramesh M, Yura T, Dhakshinamoorthy S, Kannt A. Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2022 Sep 14;12(1):15440. doi: 10.1038/s41598-022-19634-2. PMID: 36104373; PMCID: PMC9474883.
  4. Schiffmann S, Gunne S, Ulshöfer T, Henke M, Roser LA, Schneider AK, Cinatl J, Thomas D, Schreiber Y, Wagner PV, Grünweller A, Parnham MJ. In Vitro Safety, Off-Target and Bioavailability Profile of the Antiviral Compound Silvestrol. Pharmaceuticals (Basel). 2022 Aug 31;15(9):1086. doi: 10.3390/ph15091086. PMID: 36145307; PMCID: PMC9502993.
  5. de Bruin N, Schneider AK, Reus P, Talmon S, Ciesek S, Bojkova D, Cinatl J, Lodhi I, Charlesworth B, Sinclair S, Pennick G, Laughey WF, Gribbon P, Kannt A, Schiffmann S. Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection. Int J Mol Sci. 2022 Jan 19;23(3):1049. doi: 10.3390/ijms23031049. PMID: 35162972; PMCID: PMC8835123.
  6. Erkoc P, von Reumont BM, Lüddecke T, Henke M, Ulshöfer T, Vilcinskas A, Fürst R, Schiffmann S. The Pharmacological Potential of Novel Melittin Variants from the Honeybee and Solitary Bees against Inflammation and Cancer. Toxins (Basel). 2022 Nov 22;14(12):818. doi: 10.3390/toxins14120818. PMID: 36548715; PMCID: PMC9786170.
  7. Veleanu A, Kelch MA, Ye C, Flohr M, Wilhelm A, Widera M, Martinez-Sobrido L, Ciesek S, Toptan T. Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection Kinetics. Viruses. 2022 Sep 12;14(9):2017. doi: 10.3390/v14092017. PMID: 36146823; PMCID: PMC9506066.

2023

1. Gruber J, Hanssen R, Qubad M, Bouzouina A, Schack V, Sochor H, Schiweck C, Aichholzer M, Matura S, Slattery DA, Zopf Y, Borgland SL, Reif A, Thanarajah SE. Impact of insulin and insulin resistance on brain dopamine signalling and reward processing - An underexplored mechanism in the pathophysiology of depression? Neurosci Biobehav Rev. 2023 Jun;149:105179. doi:10.1016/j.neubiorev.2023.105179. Epub 2023 Apr 12. PMID: 37059404

2.Aichholzer M, Schiweck C, Uckermark C, Hamzehloiya T, Reif-Leonhard C, Golbach R, Reif A, Edwin Thanarajah S. Impact of COVID-19 on the treatment of depressive patients in Germany-a gap in care for the mentally ill? Front Psychiatry. 2023 Sep 27;14:1198632.doi:10.3389/fpsyt.2023.1198632. PMID:37840810; PMCID: PMC10569605

3. Bormann M, Brochhagen L, Alt M, Otte M, Thümmler L, van de Sand L, Kraiselburd I, Thomas A, Gosch J, Braß P, Ciesek S, Widera M, Dolff S, Dittmer U, Witzke O, Meyer F, Lindemann M, Schönfeld A, Rohn H, Krawczyk A. Immune responses in COVID-19 patients during breakthrough infection with SARS-CoV-2 variants Delta, Omicron-BA.1 and Omicron-BA.5. Front Immunol. 2023 Jul 13;14:1150667. doi: 10.3389/fimmu.2023.1150667. PMID: 37520539; PMCID: PMC10372796

4. Roesmann F, Jakobsche I, Pallas C, Wilhelm A, Raffel J, Kohmer N, Toptan T, Berger A, Goetsch U, Ciesek S, Widera M. Comparison of the Ct-values for genomic and subgenomic SARS-CoV-2 RNA reveals limited predictive value for the presence of replication competent virus. J Clin Virol. 2023 Aug;165:105499. doi: 10.1016/j.jcv.2023.105499. Epub 2023 May 29. PMID: 37327554; PMCID: PMC10226281

5. Metzdorf K, Jacobsen H, Greweling-Pils MC, Hoffmann M, Lüddecke T, Miller F, Melcher L, Kempf AM, Nehlmeier I, Bruder D, Widera M, Ciesek S, Pöhlmann S, Čičin-Šain L. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection. Viruses. 2023 Jan 18;15(2):271. doi: 10.3390/v15020271. PMID: 36851486; PMCID: PMC9961888

6. Sisignano M, Geisslinger G. Rethinking the use of NSAIDs in early acute pain. Trends Pharmacol Sci. 2023 Apr;44(4):193-195. doi: 10.1016/j.tips.2023.01.001. Epub 2023 Jan 26. PMID: 36707386

7. Bauer R, Meyer SP, Raue R, Palmer MA, Guerrero Ruiz VM, Cardamone G, Rösser S, Heffels M, Roesmann F, Wilhelm A, Lütjohann D, Zarnack K, Fuhrmann DC, Widera M, Schmid T, Brüne B. Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes. Front Immunol. 2023 Jun 12;14:1121864. doi: 10.3389/fimmu.2023.1121864. PMID: 37377965; PMCID: PMC10291055

8. Gunne S, Schwerdtner M, Henke M, Schneider AK, Keutmann L, Böttcher-Friebertshäuser E, Schiffmann S. TMPRSS2 Impacts Cytokine Expression in Murine Dendritic Cells. Biomedicines. 2023 Feb 1;11(2):419. doi: 10.3390/biomedicines11020419. PMID: 36830955; PMCID: PMC9952936

9. Sutandy FXR, Gößner I, Tascher G, Münch C. A cytosolic surveillance mechanism activates the mitochondrial UPR. Nature. 2023 Jun;618(7966):849-854. doi: 10.1038/s41586-023-06142-0. Epub 2023 Jun 7. PMID: 37286597; PMCID: PMC10284689

10. Gestal-Mato U, Herhaus L. Autophagy-dependent regulation of MHC-I molecule presentation. J Cell Biochem. 2023 May 1. doi: 10.1002/jcb.30416. Epub ahead of print. PMID: 37126231

11. Kugler S, Hahnefeld L, Kloka JA, Ginzel S, Nürenberg-Goloub E, Zinn S, Vehreschild MJ, Zacharowski K, Lindau S, Ullrich E, Burmeister J, Kohlhammer J, Schwäble J, Gurke R, Dorochow E, Bennett A, Dauth S, Campe J, Knape T, Laux V, Kannt A, Köhm M, Geisslinger G, Resch E, Behrens F. Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units. Talanta. 2023 Oct 9;268(Pt 1):125295. doi:10.1016/j.talanta.2023.125295. Epub ahead of print. PMID: 37866305